Liver cirrhosis is associated with hematologic derangements which can cause both coagulopathic and prothrombic states. However, it is less clear whether liver disease truly increases patients’ risk for intracranial hemorrhage (ICH).

A recent large retrospective cohort study found a modestly increased risk of ICH in patients with liver disease. Further prospective studies may help confirm the findings in this paper and clarify the mechanism by which liver patients are at increased risk for intracranial bleeding.


Parikh NS, Navi BB, Kumar S, Kamel H. Association between Liver Disease and Intracranial Hemorrhage. J Stroke Cerebrovasc Dis., 2015; pp. 1-5.