Should patient with severe sepsis receive steroids? Multiple trials have evaluated this question with varying results

The ADRENAL Trial sheds some light on this question. The answer: Probably not

 

TLDR:

Does hydrocortisone reduce mortality among patients with septic shock?

3800 ventilated patient’s with septic shock were randomized to receive 200mg of hydrocortisone or placebo

There was no decreased in mortality at 90 days in patients who received hydrocortisone vs those who did not

 

See a more in depth analysis here

 

This PEARL was brought to you by: Clark Owyang